Fuller was a largely self-taught pastor at Kettering who took on the hyper-Calvinism dominant among English Particular Baptists — the view that since only the elect can believe, the gospel ought not be freely offered to everyone. His The Gospel Worthy of All Acceptation argued that it should, and that the offer is genuine.

That argument cleared the ground for the Baptist Missionary Society, founded in his parlour in 1792, of which he became the first secretary and effectively the engine. When William Carey proposed going to India, he used the image of a deep mine: he would go down if others would hold the rope. Fuller held it for the next twenty-three years, raising money and defending the mission at home while Carey worked in Bengal.